Rapamycin is quite possible the drug that has attracted the most attention in the longevity world. Not only has the drug shown large effects across genders, but it has also been shown to be impact aging in multiple animal models, including yeast, worms, flies, and mice.
Rapamycin is also an FDA approved drug that millions of people have used for over 20 years as an as an immunosuppressant drug to prevent organ transplant rejection.
Rapamycin works by blocking cells from multiplying by inhibiting mTOR (mammalian target of rapamycin), the pathways that is involved in many diseases such as cancer and Alzheimer’s. By blocking this pathway, rapamycin promotes autophagy, which could potentially help extend human lifespan by preventing aging and cell death.
Although rapamycin shows a lot of promise for human longevity, more clinical trials still need to be performed before it can be considered safe for human use.