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Spannr / Glossary / Inflammation

Inflammation

Inflammation is a natural and complex biological response that occurs in the body as a protective mechanism against harmful stimuli. It is a crucial part of the immune system's defense strategy, aiming to eliminate pathogens, damaged cells, and irritants, facilitating tissue repair and healing. While acute inflammation is a normal and beneficial process, chronic inflammation can lead to various health issues. 

The Inflammatory Process

The inflammatory response is a well-coordinated series of events involving the immune system, blood vessels, and various signaling molecules. When the body detects an injury, infection, or irritation, immune cells release chemicals such as histamines and cytokines. These substances help to increase blood flow to the affected area, leading to redness and warmth, and cause blood vessels to become more permeable, allowing immune cells to reach the site of injury or infection.

Types of Inflammation

Acute Inflammation:

  • Acute inflammation is the body's immediate and early response to an injury or infection.
  • It is a short-lived process designed to eliminate the cause of cell injury, clear out damaged cells and tissues, and initiate tissue repair.
  • Common symptoms include redness, swelling, heat, and pain at the affected site. 

Chronic Inflammation:

  • Chronic inflammation is a prolonged and sustained response that can last for weeks, months, or even years.
  • It often occurs when the immune system's response is not effectively resolved or when the body is exposed to low-level irritants for an extended period.
  • Chronic inflammation is associated with various health conditions, including autoimmune diseases, cardiovascular diseases, and certain cancers.

Causes of Inflammation

  • Infection: Bacterial, viral, or fungal infections can trigger an inflammatory response as the immune system works to eliminate the invading pathogens.
  • Injury: Physical trauma, burns, or other types of injuries can lead to inflammation as the body attempts to repair damaged tissues.
  • Autoimmune Disorders: In conditions like rheumatoid arthritis and lupus, the immune system mistakenly attacks healthy tissues, causing chronic inflammation.
  • Lifestyle Factors: Poor dietary choices, lack of exercise, smoking, and excessive stress can contribute to chronic inflammation.

Managing Inflammation

  • Healthy Lifestyle: Adopting a well-balanced diet rich in anti-inflammatory foods, regular exercise, and stress management can help prevent chronic inflammation.
  • Medications: Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are commonly used to manage inflammation and reduce symptoms.
  • Rest and Recovery: Giving the body adequate time to heal after an injury is crucial to prevent prolonged inflammation.

CAR-T cells

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