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Vincere Biosciences, Inc.
1 results
In Vivo Mitochondrial Biologist
Vincere Biosciences, Inc.
Job Category
Research
Posted Date
Sep 30, 2022
Location
Cambridge, Massachusetts, USA
Full Time
Archived
In Vivo Mitochondrial Biologist
Vincere Biosciences, Inc.
Job Category
Research
Posted Date
Sep 30, 2022
Location
Cambridge, Massachusetts, USA
Full Time
Archived
Job Description
Work with drug discovery experts to elucidate impact of mitochondrial small molecules in vivo to progress these molecules to the clinic for patients.
Vincere Biosciences, a Cambridge, MA based company, is seeking highly motivated individuals to conduct grant funded in vivo research implementing published models of mitochondria- and age- related diseases. Expertise in Parkinson’s disease, cardiac models, and/or mitochondrial pathways preferred. As an early member of a growing biotech you will have the opportunity to work with a broad array of techniques, have direct interaction with the management team, and significant opportunity for influence and growth.
Specific responsibilities include:
- Design and implementation of rodent experiments to evaluate the effect of mitochondrial small molecules and understand target biology.
- Ability to work with other team members across a variety of animal models to determine effect of mitochondrial small molecules across a range of models including MPTP and D- gal in non-transgenic, Mito-QC, and Mt-Keima transgenic mice.
- Ability to work with cell biologists to isolate primary cells including cardiomyocytes.
- Read and review literature to ensure best methods and assays are employed to answer biological questions.
- Integrate learnings across disease models and tissues to develop a holistic understanding of age and disease-related mitochondrial decline.
- Develop new methods including mitochondrial biomarkers or other specialized assays.
- Analyses, integration, and interpretation of external and internal data, planning of the next set of experiments.
- Complete quantitative and qualitative assessments of experimental results.
Qualifications: The ideal individual will have:
- PhD in a cell biology related field required.
- Expertise in mitochondrial biology required.
- Experience with in vivo models involving mitochondrial function preferred.
- Experience with various readouts and assays (e.g. apoptosis, viability), biochemical Immuno assays (ELISA, Western blot, FACS) and microscopy (IHC, ICC) preferred.
- Familiarity with start up culture.
- Excellent written and verbal communication skills.
- Publication record of expertise and accomplishment in a related field.
- Excellent time management skills and ability to manage multiple projects in parallel.
- Able to work independently.
Job Type: Full-time
Schedule:
- Monday to Friday
Ability to commute/relocate:
- Cambridge, MA 02142: Reliably commute or planning to relocate before starting work (Required)
Education:
- Doctorate (Required)
Work Location: One location