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Associate Scientist, Discovery Biology
Vigil Neuroscience, Inc.
Vigil Neuroscience, Inc.
Job Description
Vigil Neuroscience is the world's first microglia-focused therapeutics company. Our purpose is clear: to treat rare and common neurodegenerative diseases by restoring the vigilance of the microglia, the sentinel cells of the brain's immune system. We are utilizing the tools of modern neuroscience drug development across multiple therapeutic modalities to rapidly deliver precision-based therapies to improve the lives of patients and their families.
Vigil is seeking a skilled and highly motivated Associate Scientist to join our Discovery Biology team. The successful candidate will have experience in cell biology, molecular biology and/or biochemistry, and will be responsible for the execution of assays for novel therapeutics targeting neuroinflammation, with a primary focus on microglia. The ideal candidate is highly organized, independent, technically creative, and excited to excel in a lab-focused, scientific role.
Key Responsibilities:
- Execution of in vitro biochemical, signaling, and functional assays using human iPSC-derived microglia and human cell lines across multiple projects.
- Culture and maintenance of cell lines and human iPSC-derived microglia to support innovative drug discovery programs.
- Run biochemical and imaging-based assays.
- Contribute to cross-functional internal project teams by presenting data and ideas to key stakeholders.
- Keeping up-to-date and well-organized records of experiments in an electronic notebook.
Candidate profile:
- Experience in culture of mammalian cells. Previous experience with human iPSC-derived microglia or other myeloid cells is a plus.
- Experience in optimization and execution of cell-based assays, as well as functional immune cell assays (AlphaLISA, HTRF, flow cytometry).
- Familiarity with western blotting, ELISA, qPCR, MSD.
- Experience with imaging-based readouts is a plus.
- Ability to multitask and work independently.
- Excellent written and oral communication skills.
- To be considered for this role, you must have a BS or MS in Biology or a related field, with typically 5+ (BS), 3+ (MS) years of relevant experience, either in industry or academia with superb technical training.
Director, FP&A
Vigil Neuroscience, Inc.
Vigil Neuroscience, Inc.
Job Description
Vigil Neuroscience is the world's first microglia-focused therapeutics company. Our purpose is clear: to treat rare and common neurodegenerative diseases by restoring the vigilance of the microglia, the sentinel cells of the brain's immune system. We are utilizing the tools of modern neuroscience drug development across multiple therapeutic modalities to rapidly deliver precision-based therapies to improve the lives of patients and their families.
Reporting to the Head of FP&A, the Director of FP&A will serve as a business partner to our Clinical team, as well as support month-end close activities, internal management reporting, and play a key role in enhancing planning & reporting capabilities.
Key Responsibilities:
- Play an integral role as business partner to the Clinical team
- Lead monthly management reporting, variance analysis, budgeting, and forecasting initiatives.
- Support Program business cases with financial and strategic analysis.
- Identify and communicate key risks and opportunities to relevant functional and program stakeholders.
- Foster cross-functional transparency and efficiency, specifically for clinical programs.
- Identify opportunities to standardize, streamline, and prioritize improvements, remove roadblocks, and increase the reliability and efficiency of planning and reporting.
- Support month-end close with budget vs. actuals analysis, troubleshooting, and collaborating with accounting and the business on key deliverables
- Support data validation and perform ad-hoc reconciliations.
- Collaborate with the Accounting team to ensure proper accruals.
- Ad-hoc analyses that support business decision making, and process / system improvement initiatives.
- Key role in enhancing Vigil’s internal reporting capabilities, including implementation of planning tool
- Support initiatives to streamline system data aggregation and reporting from NetSuite and Prendio.
- Participate in implementation and testing of new planning system implementation expected later this year.
- Other Ad-hoc initiatives to improve integration of systems with forecast and budgeting models.
Candidate profile:
Background
- BA/BS in accounting or finance; MBA is a plus.
- 7+ years of progressive experience in accounting and/or financial planning and analysis in
- pharmaceutical, biotechnology, investment banking, consulting.
- 3+ years’ experience supporting Clinical team, preferably in a high-growth biotechnology organization.
Technical
- Experience with ERP systems and associated planning and reporting tools preferred.
- Experience with NetSuite and/or Prendio a plus.
- Highly proficient in Excel based modeling.
- Strong Accounting and Financial Planning background & knowledge.
Strengths
- Strong organizational skills and attention to details.
- Demonstrated ability to balance multiple priorities in a fast paced, dynamic environment.
- Strong presentation and cross-functional partnering skills.
- Excellent problem solving and analytical skills.
- Personable, highly ethical and thrives in a collaborative environment.
- Excellent proactive communication skills (verbal and written).
- Self-motivated with high bias for action and accountability.
Associate Director, Patient Advocacy
Vigil Neuroscience, Inc.
Vigil Neuroscience, Inc.
Job Description
Vigil Neuroscience is the world's first microglia-focused therapeutics company. Our purpose is clear: to treat rare and common neurodegenerative diseases by restoring the vigilance of the microglia, the sentinel cells of the brain's immune system. We are utilizing the tools of modern neuroscience drug development across multiple therapeutic modalities to rapidly deliver precision-based therapies to improve the lives of patients and their families.
We seek an energetic, passionate, and seasoned patient advocate to join our rapidly growing company committed to patients and their families. The Associate Director, Patient Advocacy will support development and implementation of the patient advocacy strategy across Vigil’s programs. Working closely with and reporting to the VP, Patient Advocacy, this candidate will be responsible for supporting internal operations and project management as well as supporting/leading proactive external engagement with key patient advocacy groups in areas of high unmet need within the patient community. The candidate will help to build the function internally while developing and/or strengthening relationships with global, external stakeholders in rare and particularly in common neurodegenerative diseases with a focus on adult early onset populations. The candidate will be an integral member of cross functional teams and a key contributor to ensure Vigil is the partner of choice with the community through active external engagement and relationship development.
Key Responsibilities:
- Execute on and further develop the patient advocacy strategy.
- Support and further develop insight generation to ensure patient and caregiver voice are consistently integrated.
- Monitor patients@vigilneuro.com and trials@vigilneuro.com and support appropriate and compliant responses.
- Assist in managing legal/medical and regulatory review process.
- Assist in managing a budget including the submission, and tracking of sponsorship & membership requests through internal review, contracting, and payment.
- Assist in supporting and organizing Patient Advisory Boards and Councils as needed for support of clinical programs and key insight gathering.
- Serve as an internal support for events where we invite the patient community to Vigil to share their experiences, including contracts and meeting operations.
- Represent the company at key patient advocacy group conferences, medical congresses, and other patient community meetings.
- Ensure compliance with corporate policies and procedures, as well as applicable laws and regulations.
Candidate profile:
- 7+ years of experience in the pharmaceutical industry or relevant experience in non-profit advocacy organization; a mix of both is a real plus.
- Experience in neurodegeneration required with adult-onset neurodegeneration a plus.
- Experience in common neurodegenerative diseases required with rare disease a plus.
- Experience in clinical trial and drug development a plus.
- Excellent project management, communication (oral and writing) and interpersonal skills are required.
- Ability to manage and foster complex, cross functional internal and external relationships as well navigate ambiguous situations.
- Ability to travel 40% (sometimes globally) on a regular basis, as required.
- Knowledge of current regulatory requirements and guidelines governing patient advocacy as it relates to clinical research and drug development process.
- Ability to multi-task and work in a fast-paced environment
- Proven ability to work independently.
- Local candidates preferred.