Longevity Industry Jobs

The Principal Scientist within the Nonclinical Development department at Precision BioSciences will report to the VP, Nonclinical Development. The Principal Scientist has extensive pharma/biotech experience in preclinical and translational sciences to support the advancement of Precision's gene editing and cell therapy pipeline. The Principal Scientist will collaborate with external contract research organizations (CRO's), academic collaborators, and internal functions to design and execute experiments to elucidate efficacy, biomarkers of efficacy, tolerability, and potential toxicity of gene editing or cell therapy drug candidates. This individual will work independently within project teams and design studies, protocols, review data and reports, author reports, and contribute to nonclinical sections of regulatory documents and scientific manuscripts. The Principal Scientist will establish pharmacodynamic/efficacy relationships in predictive disease models and identify/evaluate biomarkers of efficacy and toxicity in a nonclinical setting and will conduct GLP studies to support regulatory filings and safety monitoring in the clinic.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

Essential Duties And Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

• As a subject matter expert, contributes to the design, execution and interpretation of nonclinical safety according to relevant regulatory requirements including review of literature and assessment of compliance
• Manage nonclinical projects as assigned, including coordination of laboratory and Precision Biosciences activities
• Develop relationships with external vendors and academic collaborators to serve as Study Monitor/Sponsor Representative for pharmacology/biodistribution/toxicity studies
• Act as study monitor when conducting GLP studies in both small (e.g., rats, mice) and large animals (e.g., nonhuman primates, canines)
• Travel to and scientifically qualify these vendors and conduct fit-for-purpose proof-of-concept and pilot animal studies
• Identify and/or develop translational biomarkers for both efficacy and toxicity readouts using in vivo models
• Provide oversight and expertise in evaluation of preclinical in vivo models relevant to specific gene therapy targets
• Serve as Translational Science and Nonclinical program representative on a multidisciplinary team of research and development scientists to progress candidates from lead optimization through NDA/BLA-enabling studies
• Support the authoring and/or review of document required for regulatory interactions and filings, regulatory compliance, and filings in support of applications for first in human studies through the provision of data and preparing reports and appropriate sections of regulatory documents as well as contribute to preparation and review of manuscripts for journal submission
• Ability to contribute nonclinical expertise and gain deep understanding of specific rare diseases across target areas focused on liver, skeletal muscle, and central nervous system disorders

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Required

• Advanced degree, M.S., Ph.D., or DVM, in a related field (Toxicology, Immunology, Biology, Biochemistry, etc.) and 14+ years of relevant experience in the pharma/biotech industry, or equivalent combination of education and experience

Preferred

• Experience with gene or cell therapies, with a thorough understanding of multiple gene editing delivery techniques, such as AAV or LNP delivery
• Experience in gene editing
• DABT certification or eligibility
• Ability to independently design experiments and analyze experimental data and present results in both nonclinical and cross-functional team settings
• Significant understanding of the role of translational research and biomarkers in relationship to efficacy and toxicity in drug development
• Experience in predictive and exploratory biomarker identification and translation from nonclinical models to a clinical setting in diverse disease areas
• Hands-on experience in development of in vivo models and design and conduct of in vivo studies for evaluation of efficacy and/or toxicity
• Excellent communication skills with ability to thrive in matrixed, cross functional teams
• Experience with outsourcing of studies at CROs and oversight of study design, budget, and program-timing
• Experience in study directing and/or study monitoring of in vivo studies, including NHP studies
• Creation of datasets and reports for regulatory filings

Travel Requirements

• Will be expected to travel (primarily domestic) potentially up to 1x/month.

Location

• This is an office-based position located at the main headquarters in Durham, NC. This role will be able to function remotely in accordance with company guidelines but is subject to change as needed.

Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS® genome editing platform. This isn’t just a statement supporting the products that we’re developing – it’s a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com

Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

If you are interested in a career opportunity with Precision BioSciences and there is not a current role that meets your experience and skills, you can apply through our General Application.

If your qualifications match our needs, you will be contacted by a member of our Talent Acquisition Team.

Warm Regards,

Precision BioSciences

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

The Manager, AAV Platform will provide leadership to the AAV Process Development and Research teams, with a focus on developing a best-in-class viral vector drug substance and drug products manufacturing platform for in vivo and ex vivo gene therapies. The ideal candidate for this position is an experienced Scientist/Engineer with a strong background in AAV biology, manufacturing and prior team leadership experience. The candidate should be proficient in upstream and downstream development, process scale-up, process optimization, and tech transfer to GMP manufacturing. This person will manage a team of Research Associates, Scientists, and Engineers and will collaborate across all functional areas to ensure project advancement, rapid and best in class execution, and communication of challenges/opportunities.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

Essential Duties And Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

• Build and lead the AAV Process Development and research teams through hiring and managing skilled personnel
• Set strategic direction for team objectives in alignment with company objectives
• Manage the daily operation of the team, including delegation of tasks, and provide technical oversight of development activities
• Support transfer of process to internal manufacturing team or to external partners as needed
• Provide mentoring and coaching to junior staff to ensure individual career development and maximize employee retention
• Work with Gene Therapy research to optimize the production of various AAV serotypes to improve efficacy and tolerability
• Work with Process analytics to develop novel tools to improve process and product understanding
• Work with MS&T to define AAV process control strategies and establish acceptance criteria
• Participate in project teams as needed and serve as SME
• Develop and manage annual capital and operating budgets
• Support the generation of test articles for IND-enabling studies and contribute to regulatory submissions as needed

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Required

• BS or MS in Chemical Engineering, Biochemistry, Biology Bioengineering, or similar discipline with 6+ years of industrial bioprocess development experience, or equivalent combination of education & experience
• Experience developing scalable AAV manufacturing processes
• Strong familiarity with downstream purification methodologies for AAV (AEX, Affinity, Ultracentrifugation, TFF)
• Strong understanding of Process Analytical Technologies (PAT), raw materials characterization and release assays for AAV
• Excellent interpersonal, verbal and written communication skills
• Ability to think critically, and demonstrated troubleshooting and problem-solving skills
• People leadership experience

Preferred

• PhD in Chemical Engineering, Biochemistry, Biology, Bioengineering, or similar discipline
• Strong familiarity with AAV biology and manufacturing strategies of different serotypes
• Ability to manage across functions, specifically Research, TechOps, Analytical, and Supply Chain
• Knowledge of Microsoft Office software suite, and statistical design of experiment software such as JMP or Minitab

Travel Requirements

• This position may require some travel (up to 10%)

Location

• This is a primarily office-based position associated with the main headquarters in Durham, NC.

Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS® genome editing platform. This isn’t just a statement supporting the products that we’re developing – it’s a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com

Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

The Data Scientist, Process Analytics is a 6 month contract position. This role will work within the Cell Therapy Process Development (CTPD) team of Precision BioSciences. This individual will lead the development of software to create, manage, and maintain a unified dataset, as well as establish data visualization tools, for the CTPD team to capture process data and related analytical readings from in-process and final drug product testing. The ideal candidate would have a baseline understanding of the CMC side of drug development to better understand user needs and logically organize the team’s data. This position is office-based with the potential for hybrid work.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

Essential Duties And Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

Primary Responsibilities Will Include

• Lead the development of laboratory data systems to gather data from various sources and consolidating them into a unified dataset
• Generating data visualization/dashboard tools based on discussion with end users
• Work with CTPD team members to establish user requirements, needs, and specifications in order to convert them to technical solutions
• Design, build, configure, and program a master database, and associated reports, forms, and interfaces
• Work with external vendors, as needed, to develop and implement data system solutions
• Support the end-user testing of various automated processes and reports against end-user requirements to ensure that these systems function as intended
• Provide day-to-day end-user support for data systems issues
• Draft, review and approve standard operating procedures (SOPs) related to data systems

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Education/Experience

Required

• Bachelor’s degree (B.S/B.A.) in computer science or related field and 2+ years of related industrial experience or equivalent combination of education and experience
• Experience working with teams to understand data system architecture and visualization requirements and develop appropriate tools
• Experience defining new database schema for client teams
• Deep knowledge of various programming languages, data architecture and/or algorithms including:
• Extensive experience with R or Python
• Proficiency with SQL
• Experience developing code that ingests and manipulates textual data from various formats (csv, xml, json, etc.)
• Development of data visualizations/dashboards using Tableau or similar program
• Experience working with data from various sources and types, including ETL mapping to integrate data from varied systems

Preferred

• Experience developing and managing pharma/biotech data systems, or other highly regulated industry
• Experience with LIMS integration
• Experience manipulating and analyzing large, high dimensional, structured, and unstructured datasets
• Familiarity with immunology and T cell biology
• Experience with statistical analysis (JMP, SAS/STAT software or equivalent)
• Understanding of drug product manufacturing and/or analytical testing

Travel Requirements

• Minimal travel is required for this position.

Location

• This is an office-based position located at the main headquarters in downtown Durham, NC, with the potential for hybrid, remote work.

Precision BioSciences’ mission and vision is to translate the world’s most powerful genome editing technology into greatly needed products throughout the life sciences, by being the conduit through which the greatest genome engineering challenges are solved. Precision’s wholly proprietary ARCUS genome editing platform enables the production of highly specific nucleases that can insert, remove, and modify DNA at essentially any location in a complex genome. Through our ARCUS platform, we are developing genome editing-based products to address critical needs in oncology, genetic disease, agriculture, and beyond. For additional information, please visit www.precisionbiosciences.com

Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Provide technical expertise and oversight of outsourced molecular, biological, impurity, compendial, biochemical, and biophysical methods for gene therapy programs
• Responsible for the review, approval, and oversight of analytical method procedures, method development reports, method validation, training/transfer protocols and reports for external analytical methods
• Analyze data and test results to monitor method performance, data trending, and support the setting or revision of specifications as part of continuous control strategy and analytical life-cycle review
• Coordinate sample and critical reagent management to support testing at internal and external testing laboratories
• Contribute to authoring of regulatory submissions
• Interface with Quality, Regulatory, and CMC functions (Analytical Development, Formulation) to present ensure quality events and technical issues are communicated and escalated appropriately
• Accountable to comply with GxP regulations, guidelines, procedures, and practices governing analytical methods for release and stability testing. Collaborate with internal and external groups cross-functionally to ensure compliance, OOS/OOT investigations, deviations, change controls and CAPAs
• Manage and monitor sample inventory, sample pulling and shipment to test sites to ensure that release and stability testing are completed within the prescribed timeframe
• With the expansion of the Gene Therapy pipeline, build and manage a team of analytical scientists

• PhD in Analytical Chemistry, Biochemistry, Cell Biology, Chemical Engineering, Molecular Biology Virology or a related discipline with 2+ years of industry experience, or equivalent combination of education and experience
• Demonstrated ability to develop, optimize, validate, and troubleshoot cGxP analytical test methods and experience in a quality control test laboratory
• Demonstrated hands-on experience with method development or testing support for at least six of the following techniques: DNA or RNA sequencing (NGS or Sanger methods), qPCR, ddPCR, biological characterization methods (bioassays, infectivity assays, potency methods, viral replication competency methods), immunoassays, impurity methods (process and product), DLS, AUC, TEM, FFF, SEC-UV/SEC-MALS, RP-HPLC/UPLC, CE-SDS, and Mass Spectrometry
• Ability to independently analyze and interpret scientific data, form conclusions, and propose solutions to analytical technical problems
• Excellent oral and written communication skills to effectively communicate with internal/external stakeholders, test sites, and to author technical documents
• Ability to work in a dynamic, cross-functional environment and to work on several different projects at the same time
• Experience using statistical software for data analysis, method robustness assessments, and trending

• Experience developing methods and/or analytical testing support/oversight for cell and gene therapy products
• Demonstrated experience with the development and implementation of methods for the analytical characterization and/or release of mRNA, lipid nanoparticles, and/or AAV
• Experience in sample and critical reagent management
• Previous experience outsourcing methods and managing analytical testing at contract testing laboratories

• This position may require up to 10 % travel

• This is an office-based position located at the main headquarters in downtown Durham, NC. For the time being, this role will be able to function remotely but is subject to change as needed.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Execute established assays and analyze data according to SOPs
• Perform Aseptic cell culture with immortalized and genetically altered cell lines
• Utilize such techniques as DNA/RNA extraction, ddPCR, qPCR, and statistical analysis
• Work collaboratively with others as part of a coordinated team
• Maintain an electronic notebook to document all experiments in a timely fashion
• Follow all internal SOPs and policies

• Currently enrolled in an accredited university program with at least three years of completed undergraduate studies in molecular biology, cell biology, or related field; or MS or PhD candidate or equivalent combination of education and experience
• Familiar with general laboratory setting/equipment, including pipettes and centrifuge
• Hands-on experience in general lab techniques, like aseptic cell culture

• Experience in gene editing
• Hands-on experience with molecular analytical techniques such as end-point PCR, qPCR, and/or dPCR
• Familiarity with genomic-based applications for qPCR/dPCR (e.g. copy number variation
• Running and analyzing data from ddPCR and qPCR readouts, and general experience with statistical software
• Familiarity with GLP practices and documentation
• Experience with data analysis and presentation tools like Excel, Prism, and JMP

• This position requires no travel.

• This is a primarily office-based position associated with the main headquarters in Durham, NC.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Assess competitive landscape for other in vivo gene correction approaches and their limitations with regards to delivery
• Emphasis on tissue-specific delivery approaches
• Interface with internal technical experts to evaluate current state of each technology
• Develop a “wish list” and prioritize, including key remaining hurdles for each technology

• Current first year full time MBA candidate or graduate student in biology/related field, or equivalent combination of education and experience
• Ability to read and evaluate scientific literature a plus

• None

• This is a primarily office-based position associated with the main headquarters in Durham, NC. For the time being, this role will be able to function remotely but is subject to change as needed.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Develop a set of programs to support ongoing studies tables/figures presentation
• Develop analysis plans for ongoing studies
• Apply statistical modeling, simulation and Bayesian methodologies for Phase II/III trials and characterizing the accuracy and limitations of these methods

• Ph.D candidate with 2+ years of study in biostatistics or statistics or equivalent combination of education and experience
• Strong SAS programming skills for handling complex data structures and reporting Table Figures Listing (TLF) modeling skills
• Excellent written and oral communication skills
• Strong organizational skills and attention to detail
• Ability to accept direction of lead team members, and manage multiple tasks and projects
• Ability to establish and maintain effective working relationships with coworkers, managers and customers

• This is a primarily office-based position associated with the main headquarters in downtown Durham, NC. For the time being, this role will be able to function remotely in accordance with company guidelines but is subject to change as needed.

• No travel is expected for this position

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Support the organization to meet reporting due dates and requirements imposed by regulators and external auditors. Support includes assistance with the preparation of monthly and quarterly internal financial reporting packages and external reporting in regulatory public filings
• Support monthly and quarterly accounting close functions including account reconciliations, vendor accruals, and other month end close analysis and reconciliations as needed
• Assist in Sarbanes Oxley testing procedures and practices including discussions with external auditors and internal audit consultant
• Assist with the preparation of quarterly cash balance reporting and forecasting for the Board of Directors’ review
• Assist with daily accounts payable responsibilities such as invoice processing and vendor account confirmations
• Build strong, open, and collaborative working relationships characterized by mutual respect with superiors, peers, and subordinates within and outside Precision BioSciences
• Any additional responsibilities or tasks as assigned

• Rising Undergraduate Junior or Senior majoring in either Accounting, Finance, Economics or related field, or equivalent combination of education and experience
• Conceptual understanding of US GAAP principles
• Intermediate proficiency of Microsoft Excel
• Ability to produce accurate quality work
• Must be detail-oriented and dependable
• Strong organizational skills
• Able to communicate data succinctly and accurately
• Ability to work with confidential information of a sensitive nature and assure it is safeguarded to protect the integrity of the company

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Characterize serum chemistry markers longitudinally in novel mouse/rat models utilizing a veterinary chemistry analyzer
• Develop methods and work instructions for a grip test apparatus in mouse models with musculoskeletal disorders
• Perform in vivo bioluminescent imaging on immunocompromised/immunocompetent mouse models utilizing the IVIS Spectrum CT
• Perform colony management tasks in mouse breeding colonies of moderately complex genetics utilizing an online database
• Administer test article via retro-orbital and tail vein injections in rodent models
• Communicate with team members regarding experimental results and updates
• Perform other tasks pertaining to basic laboratory organization and operation as needed

• Current student pursuing a BS in Biology, Zoology, Animal Science or other biological sciences or equivalent combination of education and experience
• Experience with Microsoft Office Suite preferred
• Knowledge of GraphPad Prism preferred
• Proven history of working with animals in a research or veterinary setting preferred

• Up to 50% local travel required from the Precision main office to the vivarium in Durham.

• This is a primarily office-based position associated with the main headquarters in Durham, NC but up to 50% of time will be spent at the Vivarium at a separate location in Durham, NC.

• Please note, Precision Biosciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Write, maintain, and document code for analysis of single cell RNA sequencing experiments
• Assist in the analysis of various NGS assays
• Summarize and visualize data and report to stakeholders

• Current student pursuing a Master's or PhD in bioinformatics, cell biology, genetics, immunology, neuroscience, systems biology, biochemistry, computer science, statistics or related field, or equivalent combination of education and experience
• Proficiency in one of the following programming languages: Python, R, Bash, Nextflow

• Understanding of modern sequencing techniques
• Working knowledge of biological concepts like replication, transcription, and translation
• Experience with single cell RNA sequencing analysis
• Extensive experience with data analysis using the R programming language
• Experienced using git/github for version control

• None

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Partner with laboratory based-staff members to gather, create, and improve workflows and templates related to data generation, documentation, archiving and integrity checks
• Gather key stakeholder feedback to help improve workflows
• Assist in consistent adoption of workflows and templates within the gene therapy discovery group
• Working alongside project management partners, ensure data reporting internally and externally in a consistent manner
• Document process improvement steps to allow for broader adoption

• Current student pursuing a BS or advanced degrees in science, or equivalent combination of education and experience
• Ability to summarize complex processes into clear illustrations
• Ability to translate technical tasks into workflow documents
• Knowledge or experience in project management and process improvement are beneficial but could be demonstrated through academic or volunteer experience

• None

• This is a primarily office-based position associated with the main headquarters in Durham, NC.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Assist in the development and improvement of allogeneic CAR T manufacturing processes
• Assist in the design and lead the execution of small-scale studies to assess how media components influence cell behavior
• Assist in a project that explores the possibility of using cord blood T cells as starting material in the allogenic CAR T manufacturing process
• Organize and analyze data from diverse bioanalytical data sources for presentation at group meetings
• Summarize experimental data and analysis in written reports
• Write and review technical documents including ELN entries, technical reports, batch records, work instructions, and SOPs
• Assist in general operation and maintenance of the Cell Therapy Process Development lab
• Assist in the execution of full-scale process demonstration runs
• Maintain laboratory equipment and manage consumables & reagents inventory
• Occasional after-hours and weekend work may be required

• Current undergraduate rising senior or first-year graduate student, majoring in Chemical, Biological Engineering or relevant bioscience degree, or equivalent combination of education and experience
• Preference is given to candidates with prior academic research and/or industry experience
• Basic understanding of cell biology, immunology, and engineering principles
• Cell culture or aseptic experience in a biosafety cabinet (BSC) is preferred. Preference is given to candidates with mammalian cell culture experience.
• Ability to think critically and quickly learn new skills.
• Excellent interpersonal, verbal and written communication skills.
• Ability to read, analyze, and interpret scientific literature.
• Eagerness to work in a fast-paced, collaborative environment is needed.
• Familiarity of Microsoft Office software suite is required. Use of statistical tools (JMP, Minitab, or equivalent) is highly desired.

• This position is not expected to require travel.

• This is a primarily lab-based position associated with the main company headquarters in Durham, NC.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Support the development, technology transfer, and implementation of robust manufacturing processes for allogeneic CAR Ts
• Author and review technical and manufacturing documentation (e.g. Reports and Protocols)
• Work collaboratively with Manufacturing, Quality Assurance, and support Process Development team
• Support technical trouble shooting, investigations, root cause analysis, CAPAs, impact assessment and change controls

• Current student pursuing a Bachelor’s degree (rising junior or senior preferred) or Master’s in engineering or relevant biological sciences discipline, or equivalent combination of education and experience
• Familiarity with GMP requirements
• Strong problem solving and organizational skills
• Excellent communication skills, both verbal and written, ability to interface effectively with all levels of the organization
• Autonomous, take-charge, team player with strong results oriented, positive “can-do” attitude and a sense of urgency to get things done

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Perform aseptic cell culture with primary mammalian cells or cell lines
• Execute established assays and analyze data according to SOPs
• Utilize such techniques as flow cytometry, immunoassays, and magnetic bead cell separation
• Work collaboratively with others as part of a coordinated team project
• Maintain an electronic lab notebook to document all experiments in a timely fashion

• Currently enrolled in an accredited university program with at least three years of completed undergraduate studies in biology, immunology, or related field. MS or PhD candidate is a plus.
• Familiar with general laboratory setting/equipment, including pipettes and centrifuge (required)
• Hands-on experience in general lab techniques, like aseptic mammalian cell culture (required)
• Familiarity with primary T cells (preferred)
• Running and analyzing data from multiparametric flow cytometry (preferred)
• Experience with data analysis and presentation tools like Excel, Prism, and JMP (preferred)

• This position requires no travel

• This is a primarily office-based position associated at the main headquarters in Durham, NC.

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• Learn the fundamentals of R&D program management for the BioPharm industry by phase and by function
• Become familiar with Smartsheet, an enterprise planning environment, and how to use integrated program timelines to support portfolio decision-making
• Assist PMs in standardizing program timelines regarding format, content, and level of detail
• Become familiar with Precision’s program documentation and repositories. Recommend improvements to our data management, repositories, file structure, naming convention, and retention as it pertains to R&D programs
• Help to refine our PMO Service Model, including collecting insight into business need and evaluating current tools and approaches. The output will be a proposal with recommendations, a benefit summary, and plan for communication and change management

• Current student pursuing a BS or advanced degrees in science or business, or equivalent combination of education and experience
• Knowledge or experience in project management and process improvement are beneficial but could be demonstrated through academic or volunteer experience
• Ability to engage Subject Matter Experts in documenting processes and implementing changes
• Ability to summarize complex processes into clear illustrations
• Ability to translate technical tasks into workflow documents

• Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

• This position will provide support for internal gene therapy projects. This will require characterization of candidate nucleases in mammalian cells as well as providing material for off target analysis to the Core Tech group. This intern will be expected to work with the team in cloning constructs, performing sequence analysis, extracting bacterial and mammalian DNA (either manually or using automation) and performing droplet digital PCR analysis on samples.

• Current student pursuing a Bachelor’s degree in biology or life sciences or equivalent combination of education and experience
• Basic molecular biology skills including PCR, plasmid cloning, bacterial culture inoculation and extraction of DNA, isolation of DNA from cells and tissues
• Mammalian cell culture experience is a plus
• Strong laboratory documentation skills

• No travel is anticipated for this role.

• This is a primarily office-based position associated with the main headquarters in Durham, NC. This is NOT a position that can be performed remotely, it is laboratory based.