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Scientist, Medicinal Chemistry
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
This role is an opportunity to help advance our portfolio of drug discovery projects through the design and synthesis of new chemical entities as a part of Medicinal Chemistry Team. You will work as part of multidisciplinary teams from early discovery to the delivery of drug candidates. We have 3 world class science labs onsite. A lot of the scientific work your doing in this role will be lab based. At Foghorn there is opportunity to advance your career and grow within our organization.
In This Role, You'll Get To:
- Design, plan and execute multi-step organic synthesis and purification of high-quality target molecules and solve synthetic chemistry challenges to enable expansion of available chemical space
- Analyze data sets and develop SAR using in-house and commercial in silico tools and communicate results in formal and informal settings
- Proactively seek input from computational chemistry and structural biology to collaboratively work through iterative design processes to generate novel design ideas
- Partner with CROs to enable timely delivery of target compounds
Requirements
Qualifications and skills
- BS degree in organic chemistry, in addition to 3+ years of medicinal chemistry experience in a pharmaceutical / biotechnology setting; OR an MS or PhD degree in organic chemistry
- High levels of competence in all aspects of modern synthetic chemistry, including single compound synthesis, small parallel arrays, purification methods and analytical characterization
- Significant experience and successful implementation of independent synthetic route design and problem solving
- Proven ability to work well with others in a dynamic and highly collaborative environment
Preferred Qualifications, skills, and expectations
- PhD degree in organic chemistry
- Industry experience in biotech and drug discovery in oncology preferred
- Work experience in medicinal chemistry, small molecules, and radioactive tracer
- Applied knowledge with drug design principles
- Ability to effectively present work and ideas and contribute to team discussions.
- Excellent communication skills are required
Benefits
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- 401k retirement plan with company match
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Senior Director, Lead of High Throughput Screening
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
Foghorn Therapeutics has been successful in validating our Gene Traffic Control platform by bringing two molecules into clinical development. We are now looking to capitalize of that success by investing heavily in the exciting portfolio of earlier stage assets that are underway.
This role is an exciting opportunity to be a critical part of the Drug Discovery Department of a high growth organization that is radically changing the biotech industry. We are looking for a Senior Director, Lead of High Throughput Screening (HTS) that will have an opportunity to shape Foghorn’s early discovery strategy, explore innovative screening approaches and guide hit validation efforts for multiple target classes. You will play a critical role in building a creative, inclusive, and highly collaborative work environment. This job is based in Cambridge, MA
In This Role, You'll Get To
- Lead and expand the screening group to support portfolio activities, build new capabilities internally and through external partnerships
- Design and lead hit finding and drug discovery cascades to support hit identification, hit-to-lead, and lead optimization campaigns
- Develop research solutions, evaluate and implement new assay techniques
- Employ biophysical and biochemical methods enabling mechanistic studies to determine MOA
- Mentor and guide the career development at all levels including PhD-level scientists
Requirements
- Minimum Qualifications and requirements
- PhD in Biochemistry, Biophysics, or a related field
- 7-10yrs+ years of experience in biotech/pharma industry with a track record of advancing projects from hit finding and hit-to-lead to new molecular entities (NME)
- Experience in leading discovery programs, demonstrated success in progressing small molecule hits to NMEs
- 5-10 years+ in people manager capacity with coaching and developing scientists
- Direct experience in several of the following: Assay development and HTS adaptation
- Biophysical assays (e.g. SPR, ITC, DSF, MST)
- Protein-protein interactions (PPIs)
- Cell based/phenotypic HTS
- Covalent inhibitor/binder discovery
- Fragment screening
- DEL screening
- Strong leadership skills with a commitment to rigorous science and innovative thinking
- Proven ability to manage across multiple discovery projects with a focus on delivery of results
- Experience in establishing productive relationship with CRO’s
- Proven track record of scientific excellence as evidenced by a strong publication and/or patent record
Benefits
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- 401K retirement program with company match
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid maternity leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Senior Director, Lead of High Throughput Screening HTS
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
Foghorn Therapeutics has been successful in validating our Gene Traffic Control platform by bringing two molecules into clinical development. We are now looking to capitalize of that success by investing heavily in the exciting portfolio of earlier stage assets that are underway.
This role is an exciting opportunity to be a critical part of the Drug Discovery Department of a high growth organization that is radically changing the biotech industry. We are looking for a Senior Director, Lead of High Throughput Screening (HTS) that will have an opportunity to shape Foghorn's early discovery strategy, explore innovative screening approaches and guide hit validation efforts for multiple target classes. You will play a critical role in building a creative, inclusive, and highly collaborative work environment. This job is based in Cambridge, MA
In This Role, You'll Get To:
- Lead and expand the screening group to support portfolio activities, build new capabilities internally and through external partnerships
- Design and lead hit finding and drug discovery cascades to support hit identification, hit-to-lead, and lead optimization campaigns
- Develop research solutions, evaluate and implement new assay techniques
- Employ biophysical and biochemical methods enabling mechanistic studies to determine MOA
- Mentor and guide the career development at all levels including PhD-level scientists
Requirements
Minimum Qualifications and requirements
- PhD in Biochemistry, Biophysics, or a related field
- 7-10yrs+ years of experience in biotech/pharma industry with a track record of advancing projects from hit finding and hit-to-lead to new molecular entities (NME)
- Experience in leading discovery programs, demonstrated success in progressing small molecule hits to NMEs
- 5-10 years+ in people manager capacity with coaching and developing scientists
- Direct experience in several of the following:
- Assay development and HTS adaptation
- Biophysical assays (e.g. SPR, ITC, DSF, MST)
- Protein-protein interactions (PPIs)
- Cell based/phenotypic HTS
- Covalent inhibitor/binder discovery
- Fragment screening
- DEL screening
- Strong leadership skills with a commitment to rigorous science and innovative thinking
- Proven ability to manage across multiple discovery projects with a focus on delivery of results
- Experience in establishing productive relationship with CRO's
- Proven track record of scientific excellence as evidenced by a strong publication and/or patent record
Benefits
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- 401K retirement program with company match
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid maternity leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Research Associate, Cell Culture
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
Foghorn Therapeutics has an exciting opportunity for a Research Associate, Cell Biology to join our targeted protein degradation team. We currently seek a highly motivated, creative, and collaborative researcher to join our Protein Degrader platform in a lab-based role to support early discovery projects in oncology, immuno-oncology, and other therapeutic areas. This is an onsite lab-based position in Cambridge, MA.
Requirements
Responsibilities
- Develop and optimize cellular-based assays for screening
- Support small-scale internal screening and profiling
- Evaluate and implement emerging cellular-based technologies
- Collaboratively work in a multidisciplinary team, analyze and interpret data, prepare summaries and communicate results to project teams
Qualifications and Requirements
- BA/BS in Biochemistry, Biology, Cell Biology or a related field
- Lab experience with cell culture and experience with cell-based assays are required
- Proven ability to work under limited supervision to assess assay performance and optimize assay protocol is required
Preferred qualifications, skills, and competencies
- MS in Biochemistry, Biology, Cell Biology or a related field
- 1 year+ working in a lab experience and applying cell culture skills
- Demonstrated scientific research experience
- Excellent verbal and written communication skills
- Experience with data analysis in Excel and/or GraphPad is a plus
- Experience with Western blotting, luciferase assays, and CRISPR gene editing is a plus
Benefits
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- FSA and HSA for medical expenses and dependent care expenses
- 401k program with company match
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Vice President, Biology
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
Foghorn Therapeutics has been successful in validating our Gene Traffic Control platform by bringing two molecules into clinical development. We are now looking to capitalize of that success by investing heavily in the exciting portfolio of earlier stage assets that are underway.
The Vice President, Biology will report to Chief Scientific Officer and play a critical role in the long-term growth of Foghorn Therapeutics as the company advances programs in the clinic and further builds discovery programs in the targeted oncology space. This role will lead biology research in support of Foghorn’s existing and future pipeline, and foster close collaborations with other functions including chemistry, pharmacology, drug discovery, DMPK/toxicology, degraders, translational science, and clinical research.
What you will be doing:
- Leverage and expand knowledge of current and emerging oncology clinical landscape to inform new target selection as well as the translational and clinical strategies for existing programs.
- Work with senior leadership to develop, refine, and implement the overall targeted research strategy with a specific focus on selection of development candidates (DC).
- Manage Biology and Computational Biology groups; provide scientific input, operational support, and mentorship.
- Partner with translational science and clinical research to devise research strategies that define clinical paths, pre- and post-DC selection.
- Leads biology team in finalizing nonclinical study reports and in writing regulatory documents for FIH studies.
- Collaborate effectively and align with other functions (chemistry, pharmacology, drug discovery, DMPK/toxicology, degraders, translational science, and clinical) on overall project strategies.
- Balance internal and external biology resources to support new targets, active discovery programs, and translational research.
- Ensures clear and complete record keeping for all internal and external research projects and preclinical research regulatory documents.
- Develop a science-driven, goal-oriented culture that lives Foghorn Values (People First, Data over Dogma, and Innovate to Collaborate)
- Generate ideas for novel scientific projects to be initiated by the company.
- Communicate effectively with leadership and external partners.
- Contribute to the assessment of potential new discovery targets (key scientific questions, potential lead optimization path, translational/clinical potential, competitive landscape). Provides scientific leadership for pipeline prioritization within and between indications, and within and between programs.
Requirements
About You:
- Broad oncology expertise, with a strong understanding of fundamental cancer biology and insight into the current and emerging oncology clinical landscape
- D. or M.D./Ph.D. in cancer biology or related biological science
- 15+ years of relevant industry experience in oncology and small molecule positions of increasing responsibility
- Demonstrated leadership with a passion for mentorship
- Extensive experience in managing CROs
- Research experience in transcription and chromatin biology is a plus
Benefits
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- FSA and HSA for medical expenses and dependent care expenses
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid maternity leave and 3 weeks of 100% paid leave for a non-birthing parent
- 401(k) match
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Scientist - Drug Product Development
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
At Foghorn Therapeutics, we believe in “People First, Mission Always.”
We put “People First” because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics – demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees – validated by our actions that let our people know that we care about them, their families, and their lives.
We say “Mission Always” because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of over 2.5 million people with cancer.
Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.
Our Science:
The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, impacting millions of people.
Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.
Job Summary
Foghorn Therapeutics is seeking a motivated Scientist or Sr. Scientist in drug delivery to join the drug product development group within Chemistry Manufacturing and Controls (CMC) to pursue hands-on cutting-edge formulation development and drug delivery technologies to support our portfolio. In the beginning, consistent with our entrepreneurial spirit, the scientist will be responsible to set up the CMC laboratory and to develop specialty drug delivery technologies. The Scientist/ Sr. Scientist will be mostly lab based and will be responsible to lead and execute the assessments of various innovative drug delivery technologies for development of complex parenterals and solid oral dosage forms to support Foghorn’s portfolio at both preclinical and clinical stages. Prior experience and a good understanding of one or more long acting or targeted drug delivery technologies such as nanosuspensions, liposomes, PLGA microspheres technology are preferred. The candidate will also support clinical formulation development and manufacture at CDMOs and regulatory filings. The role will report to Head of Drug Product Development.
Requirements
Minimum Qualifications
- PhD in chemical engineering, pharmaceutics, chemistry, material science or related field
- 1-2yrs or more of post-doctoral experience in drug delivery academic areas or formulation/drug delivery experience in the pharmaceutical industry
- Prior experience and a good understanding of one or more long acting or targeted drug delivery technologies such as nanosuspensions, liposomes, PLGA microspheres technology are preferred.
- Excellent scientific knowledge in formulation technologies, material science, chemistry, preformulation and formulation sciences – experience / exposure in drug delivery, complex / long acting parenterals, modified release formulation platforms are a significant plus and will be preferred.
- This role is primarily lab based
- Laboratory based skills including various drug delivery platforms, analytical characterization is a must.
- Ability to learn rapidly, have a flexible mindset and to be able to adapt to fast paced highly matrixed environments
- Effective verbal and written communication skills
- A desire to be part of a highly innovative company aimed at helping patients with serious diseases
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Research Associate - Biochemistry Biophysics
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
At Foghorn Therapeutics, we believe in "People First, Mission Always."
- Design, develop and troubleshoot in vitro biochemical and biophysical assays for both protein-protein and small molecule-protein interactions
- Profile compounds to support hit validation and lead optimization efforts
- Analyze, interpret, and document data using an Electronic Laboratory Notebook and data analysis software tools
- Work collaboratively as part of multidisciplinary team and present results to project teams
- BA/BS or MS degree in Biochemistry or Biophysics, or life sciences or biotechnology
- Demonstrated ability to analyze, interpret and present data in a clear manner
- 1-3yrs+ years of relevant industry experience
- Familiarity with automated liquid handling instrumentation is a plus
- Cell culture skills and experience with cell-based assays is a plus
- Experience with fluorescence-based assay techniques (e.g., HTRF, FP, Alpha) and label-free technologies (e.g., ITC, DSF, SPR, MST) is desired
- Ability to learn new techniques quickly and a focus on attention to detail
- Excellent communication and inter-personal skills with ability to work collaboratively on cross functional teamsi
- Highly competitive and inclusive medical, dental and vision coverage options
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Computational Chemist
Foghorn Therapeutics
Foghorn Therapeutics
Job Description
At Foghorn Therapeutics, we believe in “People First, Mission Always.”
We put “People First” because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics – demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees – validated by our actions that let our people know that we care about them, their families, and their lives.
We say “Mission Always” because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of over 2.5 million people with cancer.
Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.
Our Science:
The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, impacting millions of people.
Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.
The Role:
This scientist will play a critical role in our exciting drug discovery organization by applying state-of-the-art computational chemistry methods to generate hypotheses and design ideas to accelerate the drug discovery process.
The title of the role will be defined based on the candidate's qualifications and experience.
In This Role, You’ll Get To:
- Creatively apply computational approaches to advance drug discovery programs;
- Help to further develop the computational chemistry infrastructure and software tools within Foghorn: as a clinical phase biotech company we are always looking for the most advanced and modern tools that can help us be more efficient;
- Work in close partnership with medicinal chemists as a united compound design team to improve potency, selectivity, and ADME properties while minimizing toxicological risk;
- Develop deep understanding of project SAR, and apply cutting edge methods to identify optimal building blocks and compound design, and ultimately influence project direction
- Ph.D. in computational chemistry, or chemistry, biochemistry, biophysics with a computational focus is required.
- Experience of general molecular modeling techniques including docking, homology modeling, ligand-based and structure-based design, quantum mechanics, QSAR / machine learning, and molecular simulation
- Track record of publications and presentations
- Understanding of a wide range of current computational chemistry and cheminformatics software tools/toolkits such as Schrodinger, MOE, or OpenEye
- Experience with ligand and structure based computational chemistry activities
- Experience in complex problem solving through data mining and data analysis
- QSAR model building, method development, scientific programming (e.g. Python, Pipeline Pilot), and cheminformatics experience;
- Familiarity with high throughput screening; design and modeling of hetero-bifunctional degraders
- Demonstrated understanding of all aspects of drug discovery including medicinal chemistry and ADMET/PKPD principles
- A working knowledge of synthetic chemistry to enable independent compound design of synthetically tractable targets
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid maternity leave and 3 weeks of fully-paid paternity leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.